What is Oleanolic Acid?
Oleanolic Acid (CAS 508-02-1) is a naturally occurring pentacyclic triterpenoid compound widely found in many medicinal herbs, vegetables, and fruits. It is especially abundant in olive leaves, Ligustrum lucidum, and various traditional Chinese medicinal plants. Known for its diverse pharmacological and nutraceutical properties, Oleanolic Acid has been used in both pharmaceutical research and functional food formulations.
Chemical Information
Name: Oleanolic Acid
CAS Number: 508-02-1
Molecular Formula: C₃₀H₄₈O₃
Molecular Weight: 456.7 g/mol
Appearance: White to off-white crystalline powder
Solubility: Poorly soluble in water, soluble in ethanol and other organic solvents
Key Applications of Oleanolic Acid
1. Pharmaceutical Uses
Hepatoprotective Effects: Oleanolic Acid is widely studied for its ability to protect the liver from chemical and drug-induced damage. It is often developed into hepatoprotective drugs.
Anti-inflammatory Properties: The compound inhibits pro-inflammatory mediators, making it a potential candidate for the treatment of chronic inflammation.
Anticancer Research: Studies show Oleanolic Acid may induce apoptosis in cancer cells and inhibit tumor progression.
Antioxidant Activity: It helps neutralize free radicals and reduce oxidative stress.
2. Nutraceuticals and Functional Foods
Oleanolic Acid is incorporated into dietary supplements and functional food products targeting liver health, cardiovascular support, and immune system regulation.
3. Cosmetics and Personal Care
Due to its anti-aging and anti-inflammatory effects, Oleanolic Acid is used in skincare formulations. It helps in reducing redness, improving skin barrier function, and promoting youthful appearance.
4. Agricultural Applications
Research is ongoing to explore Oleanolic Acid as a natural plant growth regulator and biopesticide.
Global Market Trends
The demand for natural active compounds like Oleanolic Acid is increasing, driven by the shift toward plant-based pharmaceuticals and clean-label nutraceuticals. Asia-Pacific, especially China and India, remain major suppliers due to abundant botanical sources. North America and Europe show strong demand in dietary supplements and cosmetics industries.
Related Compounds
Oleanolic Acid often occurs together with Ursolic Acid (CAS 77-52-1), another triterpenoid with similar bioactivity. These compounds are frequently studied in combination for enhanced therapeutic effects.
Regulatory and Quality Considerations
Purity: Pharmaceutical and nutraceutical applications require high-purity Oleanolic Acid (≥98%).
Certificates: COA (Certificate of Analysis), GMP, and ISO certifications are important for global trade.
Compliance: Products must meet local pharmacopeia or dietary supplement regulations depending on the application.
Conclusion
Oleanolic Acid (508-02-1) is a versatile natural compound with broad applications in pharmaceuticals, nutraceuticals, cosmetics, and agriculture. With increasing interest in plant-based bioactive molecules, its global market potential is expected to expand steadily. For manufacturers, sourcing high-quality Oleanolic Acid with reliable documentation and compliance is essential for competitiveness in international markets.