Trimethoprim is a lipophilic weakly alkaline pyrimethamine-type antibacterial agent, white crystalline powder, odorless, bitter taste.
CAS: 738-70-5
Melting point: 199-203℃
Insoluble in water, ether, benzene
Slightly soluble in chloroform, methanol
Soluble in acetic acid
Product Introduction
Trimethoprim is an oral, broad-spectrum antibacterial drug suitable for urinary tract infections, respiratory tract infections, and in combination with sulfonamides for various bacterial infections.
Product Features
High-purity Raw Materials: Trimethoprim boasts a purity of 98.5-101.0%, ensuring stable and reliable efficacy.
Storage Stability: It remains stable for 24 months in a cool, dry environment, preventing loss of efficacy.
Multiple Dosage Forms: Tablets, oral solutions, and injections can be prepared to meet the needs of diverse clinical scenarios.
Quality Standard
|
Items |
Standard |
|
Appearance |
A white or yellowish-white powder |
|
Solubility |
Very slightly soluble in water, slightly soluble in alcohol, practically insoluble in ether |
|
Melting point |
199-203℃ |
|
The infrared absorption spectrum |
Is concordant with the spectrum of trimethoprim EPCRS |
|
Appearance of solution |
Not more intensely colored than reference solution BY7 |
|
Heavy metals |
≤20ppm |
|
Related substances |
≤0.2% |
|
Loss on drying |
≤1.0% |
|
Sulphated ash |
≤0.1% |
|
Assay |
98.5-101.0% |
Storage and transportation
Storage conditions: 2-8°C
We can choose air or sea transportation according to your needs, and use professional logistics channels such as FedEx, UPS, DHL, TNT, etc. to provide timely and safe delivery to ensure that your goods arrive at the designated location on time.
Company Advantages
1. We are a modern private chemical company in Hangzhou, China.
2. Our products are widely used in the food and beverage, cosmetics, and pharmaceutical industries.
3. We provide fast delivery and support small-batch orders and custom samples.
4. We strictly control product quality and employ high-standard manufacturing processes.
FAQ
Q1: What is Trimethoprim (CAS 738-70-5)?
A1: Trimethoprim is a synthetic antibacterial drug that inhibits bacterial folate metabolism. It is widely used in combination with sulfamethoxazole (SMX) as co-trimoxazole (TMP-SMX) for the treatment of bacterial infections.
Q2: What is the chemical formula and molecular weight of Trimethoprim?
A2: The molecular formula of Trimethoprim is C14H18N4O3, and the molecular weight is 290.32 g/mol.
Q3: What are the main uses of Trimethoprim?
A3: Trimethoprim is used in:Urinary tract infections (UTIs) .Respiratory tract infections .Traveler's diarrhea and gastrointestinal infections.Pneumocystis jirovecii pneumonia (PCP) prevention and treatment (in combination with SMX)
Q4: How does Trimethoprim work?
A4: Trimethoprim selectively inhibits bacterial dihydrofolate reductase (DHFR), an enzyme essential for folate metabolism and DNA synthesis. This results in the suppression of bacterial growth.
Q5: Why is Trimethoprim often combined with Sulfamethoxazole?
A5: The combination (TMP-SMX) provides a synergistic effect, blocking two steps in bacterial folate synthesis. This broadens the antibacterial spectrum and reduces the risk of resistance.
Q6: What are the common side effects of Trimethoprim?
A6: Side effects may include:Nausea, vomiting, and rash.Hyperkalemia (elevated potassium levels).Bone marrow suppression (rare but serious).Hypersensitivity reactions
Q7: Is Trimethoprim safe for pregnant women?
A7: Trimethoprim may interfere with folate metabolism, so its use during pregnancy requires caution and medical supervision. Folic acid supplementation may be recommended.
Q8: How should Trimethoprim be stored?
A8: Store in a cool, dry place at room temperature, away from light and moisture. Follow pharmaceutical storage guidelines for medical-grade products.
Q9: What industries or fields use Trimethoprim?
A9:Pharmaceutical industry: production of antibiotics and formulations.Veterinary medicine: used in some animal infection treatments.Microbiology research: studying antibacterial resistance mechanisms
Q10: Where can Trimethoprim (CAS 738-70-5) be obtained?
A10: Trimethoprim can be sourced from licensed pharmaceutical manufacturers and research chemical suppliers. Buyers must ensure compliance with local drug regulations.
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