Products Description
Mycophenolate mofetil is a precursor of active mycophenolic acid (MPA), an immunosuppressive component extracted from Penicillium culture medium. It is an inhibitor of inosine mononucleotide dehydrogenase (IMPDH), an enzyme essential for the synthesis of guanine nucleotides, especially for the classical synthesis of guanine nucleotides required by lymphocytes.
Application
Mycophenolate mofetil is a prodrug produced by nonspecific esterase cleavage in vivo to generate the parent compound mycophenolic acid. Mycophenolic acid blocks inosine monophosphate dehydrogenase and is an effective immunosuppressant.
Quality Standard
|
Items |
Standard |
|
Appearance |
White crystalline powder |
|
Heavy metal |
≤20ppm |
|
Loss on drying |
≤0.5% |
|
Residue on ignition |
≤0.1% |
|
Assay |
98.0~102.0% |
|
Organic impurities |
Mycophenolic acid: ≤0.50% Mycophenolate Mofetil related compound A: ≤0.10% Mycophenolate Mofetil related compound B: ≤0.10% N-Oxide analog: ≤0.10% 1-Morpholinoethoxy analog: ≤0.10% Z-Mycophenolate mofetil ≤0.10% O-Methyl analog: ≤0.10% Methyl mycophenolate: ≤0.10% Any single unspecified impurity: ≤0.10% Total impurities: ≤0.70% |
|
Residual solvent |
Xylene: ≤2170ppm Ethyl acetate: ≤5000ppm Benzene: ≤2ppm Chlorohydrin: ≤50ppm 2-Morpholinoethanol: ≤1000ppm |
Storage and transportation
Storage conditions:
Store DMSO or ethanol solutions at -20° for up to 1 month
Marketing
Our products are sold well in more than 60 countries and regions including North America, Western Europe, Southeast Asia, Central and South America, etc. We have established long-term and stable cooperative relations with pharmaceutical companies in Europe, the United States, Greece, Germany, Iran, Russia, South Korea, India and other countries.
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