L-histidine is a white crystal or crystalline powder. It softens at 277°C and decomposes at 287°C. Its solubility in water at 25°C is 41.9 g/L. It is slightly soluble in alcohol, insoluble in ether and chloroform, and tastes sweet. CAS No.: 71-00-1, Molecular formula: C6H9N3O2, Molecular weight: 155.15, EINECS No.: 200-745-3.
Products Description
Good solubility
At a room temperature of 25°C, the solubility of L-histidine in water is as high as 41.9 g/L. The liquid after dissolution is clear and transparent and can be directly used to prepare amino acid injections and scientific research reagents, with excellent compatibility.
Optical consistency
The optical rotation is adjusted by optical rotation precision control equipment to keep the specific rotation of L-histidine at +12.6º to +14º, ensuring the optical activity of the product molecular structure is stable and suitable for precision drug development.
Moderate pH
Using professional buffer control technology, the pH value of L-histidine aqueous solution is controlled between 7.0 and 8.5, which is suitable for most clinical injections and cell culture systems and enhances system stability.
Application
- Medical field: used for amino acid injection, nutritional supplements, and treatment of gastric ulcers, anemia, cardiovascular disease, etc.
- Nutritional supplement: as an essential amino acid for the human body, used in health food, sports nutrition, and special medical formula food.
- Scientific research use: widely used in biochemical experimental systems such as cell culture, microbial fermentation, protein synthesis, and metabolic pathway research.
- Biochemical preparation: as an important component of compound amino acid injection and histamine synthesis.
Scope of use
According to national standards, the recommended addition amount of L-histidine 71-00-1 is 1/1000~3/1000, depending on the application and formulation requirements.
Storage and transportation
To ensure stable performance, L-histidine 71-00-1 should be stored in a dry and sealed environment at 2~8°C, away from moisture and direct sunlight.
Quality Standard
|
Items |
Standard |
|
Appearance |
White crystals or crystalline powder |
|
Assay |
98.5%-101.5% |
|
Residue on ignition |
≤0.4% |
|
Chloride (CI) |
≤0.05% |
|
Sulfate (SO4) |
≤0.03% |
|
Iron (Fe) |
≤30ppm |
|
Heavy metal (Pb) |
≤15ppm |
|
Related compounds |
Not more than 0.5% of any individual impurity is found; Not more than 2.0% of total impurities are found |
|
Specific rotation |
+12.6º - +14º |
|
PH |
7.0-8.5 |
|
Loss on drying |
≤0.2% |
Marketing
Our products are well-received in over 60 countries and regions, including North America, Western Europe, Southeast Asia, and Central and South America. We have built long-term, stable partnerships with pharmaceutical companies across Europe, the United States, Greece, Germany, Iran, Russia, South Korea, India, and other markets.
FAQ
Q: What is L-histidine?
A: L-histidine 71-00-1 is a natural essential amino acid with a molecular formula of C₆H₉N₃O₂. It is commonly used in medicine, nutritional supplements, and scientific research. It has the functions of regulating metabolism, synthesizing proteins, and generating histamine.
Q: What are the appearance characteristics of L-histidine?
A: The product is white crystals or crystalline powder with a slightly sweet taste. It is insoluble in ethanol and chloroform, and its solubility in water is 41.9 g/L (25°C).
Q: What is the purity standard of L-histidine?
A: Its content is generally controlled between 98.5%-101.5%, which meets the quality requirements of pharmacopoeias such as EP and USP, and is suitable for medicine and high-end scientific research purposes.
Q: What industries can L-histidine be used in?
A: It is widely used in the fields of the pharmaceutical industry, nutritional health food, bioengineering, cell culture, protein expression, and biochemical research.
Q: What are the storage conditions of L-histidine?
A: It is recommended to store in a dry, sealed environment at 2~8°C, away from moisture, high temperature, or direct sunlight to ensure product stability.
Q: Does it contain animal-derived ingredients?
A: No. L-histidine 71-00-1 is produced by a microbial fermentation process and has no animal-derived ingredients. It is suitable for cell culture and application scenarios that meet the animal-free ingredient specification.
Q: What is the recommended addition amount of L-histidine?
A: According to national standards, the recommended addition amount is 1/1000 to 3/1000, which is adjusted according to the product formula and purpose.
Q: What is the pH range of L-histidine?
A: The pH of the aqueous solution is generally controlled between 7.0–8.5, which is suitable for a variety of biological preparations and injection environments.
Q: What are the impurity control indicators?
A: Heavy metals (Pb) ≤15 ppm, iron (Fe) ≤30 ppm, ignition residue ≤0.4%, single impurity ≤0.5%, total impurities not exceeding 2.0%.
Q: Is L-histidine supported for pharmaceutical use?
A: Yes, the product meets pharmaceutical grade standards and can be used for compound amino acid injections, therapeutic preparations, and other clinical application formulations.
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